ea0013p129 | Growth and development | SFEBES2007
Pemberton Helen
, Franklyn Jayne
, Boelaert Kristien
, Chan Shiao
, Kim Caroline
, Cheng Sheue-Yann
, Kilby Mark
, Mccabe Christopher
The key mitotic regulator pituitary tumor transforming gene (PTTG) is expressed at low levels in fetal brain compared with adult, and modulates the proliferation of human embryonic neuronal N-Tera2 (NT2) cells. We examined the function and expression of PTTGs interacting partner separase, along with Rad21, the functional component of cohesin, which is cleaved by separase following interaction with PTTG. In contrast to PTTG, the cleaved forms of separase and Rad21 were hi...